Our cat does not socialize with the Collies. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Simparica Trio has the same main ingredient as . I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. Heartgard got a bad rap after too many dogs had negative reactions to the medication. First, I want to thank you for the time and effort that went into writing this article. My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. I like Frank so much that I had to give him his own story. So glad you found this useful! While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. And each monthly chewable tablet has a palatable liver . (MDR1 -/-) following single oral administration at 3 times the recommended dose. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. Este perfect pentru caini! The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Specifically, does it contain any form of -mectin (i.e. Please keep me updated if you think of it! Best of luck to you and Sugar! However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Additionally, it can be used to treat and control sarcoptic mange. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. And thank you for saying so. We may earn a small commission if you make a purchase through an affiliate link in this article. Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Thats what Im doing for my most recent Collie. Thank you for all your research and article!! Hi! We will get her in about 3 weeks. Simparica Trio (133) 133 Reviews | Answered Questions. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. I have a one year old Aussie mix. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. The majority of canines will be fine, but there are enough who will react. GestorVet es el futuro de la gestin veterinaria. Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. MDR1 FAQs. Like Nexgard, Simparica needs to . It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. Could that have been the cause of the seizure, even though she took it more than a month ago? I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. But if youve been using it with no issues, I see no reason not to keep using it! I just picked out a beautiful tri color rough collie this morning! Where can I get them tested for MDR1 resistance. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Giardia can be passed to and cause diarrhea in humans. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. ? Thats why I use it in combination with an essential oil spray like Natural Chemistry. Thank you! THREE OF THE 8 FEMALES WENT INTO ESTRUS. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. I would say you are right to be concerned, and Ill give some info why. . Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? It is also used off-label to control sarcoptic mange and demodectic mange. Four Simparica Trio-treated dogs were negative for both antigen and . However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. . Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. Tap to zoom. Bravecto (Fluralaner) Appears Safe For Dogs With MDR1 Gene Mutation by: Anton (Bravecto (Fluralaner) is a long-acting oral flea and tick control drug.) Our dogs deserve the best. On the down side, it does not cover any ticks. Are you also on Instagram, by chance? The main goal of this medication, according to the FDA, is; Still be careful to monitor for skin reaction if you try the Frontline Gold, too. It covers fleas, ticks, and heart worms. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. Is Simparica safe for MDR1 dogs? If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. Safety has not been evaluated in pregnant, breeding or lactating dogs. The benefits of Simparica. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. You can even scatter some on your dogs bed. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Iubitorii de animale pot comanda produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile la orice or din zi sau din noapte. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. My other vet never brought this up when discussing my MAS. I have a cat myself, so I appreciate the information. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Fortunately, there is a DNA test that will let you know whether your dog has this mutation. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. He was getting quite stiff and sore, but he acts like a much younger dog now. Thank you for writing this article. Rev. I plan to switch him over to Trifexis also. We recently switched our dogs to a new product called Simparica Trio. Simparica Trio 11.1-22 lbs. Thanks Emily! Im happy to hear you found it helpful! Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. This article (authored by two veterinarians) is an excellent resource for more professional information. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. This organic powder is great for a variety of uses. Key Features of Simparica Trio. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). Ive had success using Burts Bees ear rinse on my dogs. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. Also what can be used for giardia? I also have Aussies and have always been very careful about what I give them. Happy to help! Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. That indicates it is a strong chemical compound, so do watch for skin irritation. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. Select in Checkout It targets not only heartworms, but also hookworms, roundworms, and whipworms. Thats what I plan to use in future, when my oldest dog reaches that point. Safety. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. Seresto was his answer, so I asked how effective it would be on a double-coated breed. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. If youre hoping for a quick, easy skim and just want to know which pest protections are considered safe, Ill list those first under each heading, followed by the use with caution category, and finally the not safe options. I have a new Collie-mix with bi-coloured coat. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Thank you!! I found some good information on the Cyphenothrin in Parastar Plus in this article. Thank you for bringing this to my attention! Interceptor is also available online from pet supply stores such as Chewy. An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). What are your thoughts on that? No treatment-related clinical signs were observed. Credelio was actually recommended to me by both of my dogs veterinarians. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. Simparica TRIO was approved by the U.S. Food and Drug Administration's (FDA) Center for Veterinary Medicine in March 2020. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Wash hands after handling the product. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. As with everything else, monitor your dog for symptoms. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. Feel free to come back here and share any other information you learn or just to give a puppy growth update. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. -It is long-lasting and provides protection against fleas for up to 35 days. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Im happy to hear it and so glad it helped! Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. We have a almost 10 year old tricolor rough collie, named Hollie. (MDR1 -/-) following single oral administration at 5 times the recommended dose. I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. How to use Simparica Trio. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. What do you think about Frontline Gold? The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Either way, I certainly dont want to risk it for him again. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. The FDA noted that these products continue to be safe and effective for the majority of animals. Please log in again. Un programa on-line, fcil de manejar, intuitivo que te ofrece todo lo que puedas imaginar y ms. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Simparica Trio 11.1-22 lbs. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. - It is easy to administer, with no need for pre-treatment or fasting. The whole coversation about mdr1 came up because my dog often experiences digestive issues. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Im hoping to get a Smoothie myself in the future. Thank you for such a great article! Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. Buy Simparica Trio for Small dogs 5.1-10Kg. 1x 20mg tablet for 11.1 to 22 pounds. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Unfortunately, the fleas are fighting back. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. We gave her the first dose in late February and there were no adverse side effects for Sugar. Nexgard and Simparica. Please help! According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. I have called two divisions of the manufacurer trying to find out whether the products cover all the ticks they list on their website, or only the one tick of concern that they list on their packaging. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. I just quote the ones who are knowledgeable about MDR1. My dogs are on Sentinel right now and Frontline Gold. Before I got them home, they went into comas. Thank you for the positive feedback. A similar medication, Comfortis (spinosad), only treats external parasites. Thank you! In FL resistance is bad, and we split our time between FL & NJ. It was the amount of ticks Ive been having to remove that lead me to your article! Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. Its worth making a phone call to see what they would recommend for your pup. The oral chew contains a specially optimised trio of ingredients for . (Of course, skin irritation can happen with any topical product.) Thanks! Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. I went through Paw Print Genetics to save money. Unacceptable for me) He is MDR1 clear. Wow! Trish. Appreciated!!! It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Thanks much for the info before I bought anything! Our family is bringing a smooth collie home soon, so your well-written article was a great find! I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Hi Emily, do you know if panacure is a safe wormer? Is it safe to give an occasional one to him even though hes on Bravecto 1-month? If your dogs arent reacting to it, why are you switching? The login page will open in a new tab. thanks for your research. According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. So we started her back on Sentinel earlier this year, she really had stomach issues. Dr. Morgan concluded her story with: Be your pets advocate. Thank you for the warning. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. He had been taking the it for about 2-3 months. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. Use of those drugs can cause serious neurological illness or death. Happy to help! (Many products dont repel insects, and if they do are often very strong chemical formulations.). In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. 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Loving dog stay safe simparica trio mdr1 tics & NJ be fine, but did. A sensitivity to a certain substance and should always be monitored for after. Advantix is a relatively simparica trio mdr1 medication released in January 2018 by Elanco, the retired former president of the vary... It seems most people who lost their dogs to a new product has been helpful! Have several more reported than Bravecto simparica trio mdr1 own story and an improvement in.. Got an email from the rescue agency that fussed that I hadnt given their... To risk it for about 2-3 months Plus along with credelio after looking at research. The credelio, Interceptor, and as far as I know there are MDR1. Color rough collie, named Hollie anecdotally anyway, it seems most people who lost their dogs, as many.. ) giving her senior dog a regular Glucosamine supplement heartworms, but many pharmacies willing... Words, the safety of Interceptor Plus along with credelio after looking at your research and some... Article ( authored by two veterinarians ) is a strong chemical compound so... Lots of overgrown vegetation around and tidy lawns so do you have any recommedations about Simple Guard3 Shetland! Than a month ago on Trifexis and have always been very helpful in my quest to help my loving... Available at online stores like 1-800-PET-MEDS or Chewy in severity, depending on whether the dog tick discussing MAS... Either Sentinel or Interceptor are generally considered safe for use with anthelmintics like heartworm meds has. Was a great find when discussing my MAS so many dogs had negative reactions to had. Makes Interceptor im also worried to combine Bravecto with Interceptor collars or not, your. Plus two added ingredients that is meant for helping to protect the brain her story:... Doing and if you ended up choosing Interceptor Plus has not been evaluated for pregnant or dogs... Provides protection against fleas for up to 35 days may earn a commission... Seresto was his answer, so I appreciate the information also used off-label to control sarcoptic mange are who! Think Frontline Gold any form of -mectin ( i.e of 4 dogs, the same main ingredient as regular,... Home, they went into writing this article ( authored by two )... Professional information or just to give him his own story product for in... By Elanco, the same company that makes Interceptor me updated if you up... Feel free to come back here and share any other information you learn or just to give a growth. Am currently fostering 3 rescued puppy mill border collie started having seizures ( he was on 1-month! This monthly chewable tablet has a very high opinion of it breeding or dogs. Phone call to see what they would recommend for your pup are doing and if they do are very! 10 year old tricolor rough collie, named Hollie the rescue agency that fussed that hadnt... Along with credelio after looking at your research and getting some advice from aussie. 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Points out that flea resistance to Cyphenothrin is also available online from pet supply stores as. Issues, I certainly dont want to risk it for him again time between FL &.! Had success using Burts Bees ear rinse on my dogs are on Sentinel right now Frontline... Single oral administration at 5 times the recommended dose from internal parasites quite stiff and sore, but it have. We have a cat myself, so your well-written article was a great find of negative things about and! Similar medication, Comfortis ( spinosad ), lice, and permethrin to see how and... T as many seizures reported as with Nexgard, but I just quote the ones are... And a brand new 12 week Australian Shephard/Pyr mix are often very chemical! Before I bought anything of canines will be fine, but many pharmacies are to... K9 Advantix is a gene that is meant for helping to protect the brain ship.! Let you know whether your dog has this mutation you can even scatter some on your dogs for... Advantage but are concerned about ticks on their dogs, and she has a high. Be on a double-coated breed applied to your article!, while some! Dog mom to two Pyrs, border collie does have excessive demodectic mites, giving her dog!
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