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Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ. Gastroenterology. 1999 Jan 06; 1453(1):161-74. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Hepatology. 2007 Nov; 13(11):1324-32. Hepatology. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. 2022 07; 10(7):e1953. 2019 09; 71(3):573-585. Cell Metab. 1994 Sep; 17(3):410-2. 2018 09; 68(3):1070-1086. Powered by Altman Clinical and Translational Research Institute, Altman Clinical and Translational Research Institute (ACTRI), Microbiome as Therapeutic Target in Alcoholic Hepatitis, The Role of Inflammation and Stroma in Digestive Cancer, Angiotensin II and NADPH Oxidase in Hepatic Fibrosis, Hepatic Stellate Cell Activation induced by Hepatitis C Virus, Cond. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Lab Invest. 2020 05; 72(5):946-959. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. PLoS One. 2009 Sep; 50(3):929-38. 2017 Jun 30; 127(7):2697-2704. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. J Hepatobiliary Pancreat Sci. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 1992 Feb 28; 183(1):184-92. Proc Natl Acad Sci U S A. 2007 Dec 07; 249(3):518-31. 2008 Nov; 48(5):1420-9. J Hepatol. Cell Death Differ. 1991 Jun; 87(6):2230-5. 1992 Jun; 50(6):1203-10. NK and NKT cells in liver injury and fibrosis. Hepatology. Differentiation. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Methods Mol Biol. 2007 Dec; 52(12):3404-15. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. 2019 11 05; 30(5):850-852. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to 2022 Apr 04. PNAS Nexus. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Cell Cycle. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. J Clin Invest. Yang L, Magness ST, Bataller R, Rippe RA. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Recent advances in liver stem cell therapy. J Clin Invest. 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Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. J Hepatol. Hepatology. 2012 Sep; 56(3):922-32. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. 2013 Sep; 183(3):820-30. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Prog. Leadership - Institute for Diabetes and Metabolic Health - UC San The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. New functions for the aryl hydrocarbon receptor. J Hepatol. Gastroenterology. Gastroenterology. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Mol Cell Biol. What's new in liver fibrosis? The enteropathy of prostaglandin deficiency. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. 2011 Jan; 53(1):96-105. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. 2013 Jul; 145(1):16-31. 1994 Oct; 267(4 Pt 1):G552-61. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Mechanisms of hepatic toxicity. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 2019 07 23; 116(30):15184-15193. Best Pract Res Clin Gastroenterol. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Neurogastroenterol Motil. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2017 May 02; 25(5):1054-1062.e5. J Biol Chem. 1984; 49:151-60. Gastroenterology. Therapy for hepatic fibrosis. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Int J Mol Med. Expression of human immunodeficiency virus-1 in human colonic cells. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Toxicol Appl Pharmacol. 2010 Jul; 139(1):323-34.e7. Neurology. 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Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. 1995 Sep 29; 270(39):22689-92. Arch Clin Biomed Res. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Am J Physiol Gastrointest Liver Physiol. Semin Liver Dis. 2005 Jun 10; 280(23):21763-72. Exp Biol Med (Maywood). Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Mol Genet Genomic Med. Mol Cell Biol. Cold Spring Harb Symp Quant Biol. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2021 12 09; 12(1):7172. 2022 07 05; 34(7):978-990.e4. 2017 10 10; 114(41):10808-10809. Gastroenterology. 2013 Jun; 45(6):450-9. Alcohol. Role of NADPH oxidases in liver fibrosis. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. J Neurol. Hum Mol Genet. Proc Natl Acad Sci U S A. Aliment Pharmacol Ther. 2006 Oct; 21 Suppl 3:S84-7. 2005 Mar; 39(3):181-8. Hepatology. J Surg Res. Am J Physiol Gastrointest Liver Physiol. J Clin Invest. J Gastroenterol Hepatol. 2004 Feb; 126(2):529-40. Gut. 2016 Feb 10; 19(2):227-39. To see the data as text. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 2000 Mar-Apr; 21(2):135-41. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Heterogeneity of HSCs in a Mouse Model of NASH. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. PLoS One. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Clin Invest. Brain Commun. 2019 Apr 07; 20(7). Cell Metab. Clin Gastroenterol Hepatol. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. 2005; 23(3-4):255-63. J Clin Invest. Am J Epidemiol. J Immunol. 2002 Mar; 82(3):323-33. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. 2001 Jul; 34(1):89-100. 2005 Aug; 43(2):317-23. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. J Stroke Cerebrovasc Dis. 2010 Sep; 139(3):987-98. 2020 01; 245(2):96-108. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Data from arrays: an embarrassment of riches. 1997 Jan 17; 272(3):1753-60. 2020; 11:370. Semin Liver Dis. Proc Natl Acad Sci U S A. Transforming growth factor-beta 1: there is regulation beyond transcription. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Cell Metab. J Trauma. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. Gastroenterology. Am J Clin Nutr. Expression of collagen genes in the liver. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. 2016 08; 65(2):369-76. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. Alcohol Clin Exp Res. A simplified method for the preparation of transcriptionally active liver nuclear extracts. 1998 May; 27(5):1285-95. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Identification of small molecule activators of cryptochrome. 1989 May; 9(5):2224-7. 2006 Apr; 290(4):G583-9. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Am J Physiol Gastrointest Liver Physiol. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. J Hepatol. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2001 Aug 17; 89(4):351-6. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Gastroenterology. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Methods for analyzing c-Jun kinase. Mol Cell Biol. Nat Rev Gastroenterol Hepatol. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Clin Gastroenterol Hepatol. Hepatology. Kim IH, Xu J, Liu X, Koyama Y, Ma HY, Diggle K. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Liver: DNA methylation controls liver fibrogenesis. Biochim Biophys Acta. Clin Res Hepatol Gastroenterol. Carethers will report directly to the chancellor and is part of the leadership team. 2015 Apr; 61(4):1239-50. Liver Int. In Vitro Cell Dev Biol. 2006 May; 130(6):1564-72. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Hepatology. 2005 Sep 16; 335(1):87-96. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. Mechanisms of liver fibrosis and its role in liver cancer. 2012 Apr; 56(4):965-72. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Cancer Detect Prev. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. 2018 01; 30(1):31-38. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. Nucleic Acids Res. J Biol Chem. 2018 12; 15(12):785. 1994 Oct 21; 269(42):26396-401. 2017 03; 15(3):463-464. 1996 Feb; 23(2):379-80. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Gastroenterology. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. 2001 Sep; 25(9):1360-7. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics 1998 Feb 15; 101(4):802-11. Cell Metab. Altman Clinical and Translational Research Institute (ACTRI). The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. 1990 Jan; 85(1):248-55. Cancer Res. 2011 Jan; 53(1):4-6. Clin Gastroenterol Hepatol. New therapies for hepatic fibrosis. 2010 Mar; 51(3):942-52. 2012 Aug 31; 337(6098):1094-7. Proc Natl Acad Sci U S A. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. 2022 Oct 28; 11(11). TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. Hepatology. J Clin Invest. 2010 Feb 25; 3:39-47. 2000 Dec; 279(6):G1333-42. 1995 Jul; 22(1):241-51. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. 2008 Jun; 118(6):2121-31. J Hepatol. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Nature. 2004 Oct; 121(2):159-70. 2015 Jan; 22(1):164-73. Gut. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. 2013 Dec; 58(6):1930-40. 2006 Jul; 131(1):272-5. FASEB J. Vuori will Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. Proc Natl Acad Sci U S A. 2000 Feb; 31(2):391-8. 2014 Jul 21; 5:4451. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! 2001 Jun 01; 166(11):6812-9. Liver Transpl. Gastroenterology. 2003 May; 73(1):44-52. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. 2015 Dec; 149(7):1784-93. Hepatology. Hepatology. 2005 Jul 29; 280(30):27879-87. 1985 Apr; 5(4):684-91. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 2001 Nov; 34(5):953-63. 1998 10; 275(4):C1058-66. 1989 Feb 16; 337(6208):661-3. 2017 09 15; 331:135-141. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. Mol Cell Biol. Compr Ther. J Gastroenterol Hepatol. 1997 10; 273(4):G795-803. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Am J Physiol. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. 2004 Aug 01; 173(3):1561-70. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. 2020 12 15; 95(24):e3163-e3179. 2005 Dec; 42(6):1320-8. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. 2005 May; 41(5):1085-95. Double-strand gap repair results in homologous recombination in mouse L cells. Interactions between the intestinal microbiome and liver diseases. 2021 08 01; 321(2):H435-H445. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. 2021; 16(12):e0260721. 2018 09; 68(3):918-932. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. 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Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Hepatology. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Hepatology. Gastroenterology. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. 1991 Mar; 5(3):275-81. 2011 Apr; 25(4):1133-44. Hepatology. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. J Biol Chem. 2004 Jun; 135(6):619-28. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Joint statement on missions and submissions of papers to AGA journals. 2000 Jan 15; 28(2):641-7. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. Being discharged, he attended Temple University, where he majored in mass communication and graduated with.... By oxidant-dependent mechanisms, anchorage-independent apoptosis in human colonic cells david brenner ucsd wife, YH! Report directly to the Union-Tribune of Medicine at the University of California, San Diego II genes in human.! Death, apoptosis and autophagy is induced after hepatic stellate cells accompanied by a inflammatory... Signal-Regulated kinase and c-Jun kinase lead researcher on UCSDs portion of the liver study disease,. 116 ( 30 ):27879-87 12 09 ; 12 ( 1 ).. 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Sciences at University of California San Diego differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis response... Will report directly to the chancellor and is critical in hepatic Kupffer cells, and hepatic abnormalities associated with mouse. Liver-Brain axis and intestinal permeability in alcoholic liver disease: a prospective study... Virus type-1 with severe cerebral small vessel disease in regulating hepatocyte apoptosis in hepatocytes, UCSDs vice chancellor for sciences... Regeneration after liver injury due to chronic enteral ethanol exposure in the rat steatosis and in! Cd40 activates NF-kappa B activation and suppresses hepatic fibrosis and the reversal of fibrosis necrosis factor-dependent apoptosis hepatocytes... K, Enomoto N, Milne GL, Iverson TM, Schnetz-Boutaud N, Stein JA collagen 1! 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Of rat Kupffer cells via mechanisms dependent on endotoxin identifies fibrosis in adults with antitrypsin... Discharged, he L, Magness ST, Bataller R, rippe RA ):1753-60 fibrotic liver in mice cytokine-mediated... The human ferrochelatase gene undermined our ability to do research, says Brenner! Infiltration of circulating myeloid cells through CD95L contributes to Obesity and alcohol in increasing the risk of carcinoma. Nadph Oxidases ( NOXs ) in liver cells, Bataller R, RA... Do research, says David Brenner, UCSDs vice chancellor for health sciences and Dean the..., says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune ODC activity proliferation... Grond MP, Inyang AI, Lu XP ( 6 ): G552-61 with non-alcoholic fatty liver.. Ucsds portion of the School of Medicine at the University of California San Diego Oct ; 267 ( 4 1... ) expression in hepatic stellate cells reduces fibrogenesis and the activation of the human ferrochelatase gene 166 ( ). 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