As with other medications, Synthroid can interact with. (2022). This document does not contain all possible interactions. It works by replacing thyroid hormone that is normally produced by the body. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. When the pharmacist or nurse encounters a reason for concern, they must beempowered to communicate it to the treating clinicians immediately. Levothyroxine is also used to prevent or treat a goiter (an enlarged thyroid gland) or with other therapies to treat thyroid cancer. The phase IV clinical study analyzes what interactions people who take Trazodone hydrochloride and Baclofen have. Levitra is a fast-working treatment for erectile dysfunction. Access free multiple choice questions on this topic. Avoid combinations; the risk of the interaction outweighs the benefit. They may recommend more frequent monitoring of your blood sugar level. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. For the treatment of hypothyroidism (oral): Adults who are healthy and diagnosed with hypothyroidism for a few months should receive an initial dose of 1.6 mcg/kg/day with a 12.5 to 25 mcg/day dose adjustment every 6 to 8 weeks as needed. Spironolactone interactions with alcohol Drinking alcohol while taking spironolactone can result in excessive dizziness. T3 and rT3 are then deiodinated to diiodothyronine. HEP Drug Interactions. This is because taking the drug could cause another allergic reaction. In a pooled analysis of placebo-controlled trials of antidepressants (n = 4,500 pediatrics and 77,000 adults), there was an increased risk for suicidal thoughts and behaviors in patients 24 years of age and younger receiving an antidepressant versus placebo . We study millions of patients and 5,000 more each day. Subclinical hypothyroidism occurs when your body doesnt produce enough thyroid hormones. Before Synthroid treatment, tell your doctor about any heart problems you have. The study uses data from the FDA. By sharing this information with them, you may help prevent possible interactions. Thyroid regulators Hypothyroid dosing adjustment and lab monitoring Levothyroxine dosage, lab monitoring and medication therapeutic goal Hyperthyroid medication management . Ghanavatian S, Derian A. Baclofen. Available for Android and iOS devices. If it decreases the amount of Synthroid in your body, Synthroid may not work as well as it should. eHealthMe is studying from 3,292 Levothyroxine thyroid users for its effectiveness, alternative drugs and more. Theyll likely treat these problems before prescribing Synthroid. Theyll likely monitor you more often during treatment to be sure that Synthroid is working for you. Chiha M, Samarasinghe S, Kabaker AS. Wartofsky L. Levothyroxine: therapeutic use and regulatory issues related to bioequivalence. Hypothyroidism occurs when the body doesnt produce enough thyroid hormone. In many cases, nurses will administer the drug, particularly intrathecally, and should be aware of the signs of adverse effects or excessive dosing. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. ), which permits others to distribute the work, provided that the article is not altered or used commercially. Anyetei-Anum CS, Roggero VR, Allison LA. Baclofen - Drug template done during the semester; Week 2 - Aztreonam - drug template; . Cannabis (commonly called marijuana) and cannabis products, such as cannabidiol (CBD), have been specifically reported to interact with Synthroid. Primary hypothyroidism is when the problem occurs in the thyroid gland. Monitor for signs or symptoms of overdose which may occur suddenly, especially in the initial screening phase, dose-titration phase, and reintroduction of therapy after temporary cessation of treatment. Synthroid (levothyroxine) is a prescription drug thats used to treat the following conditions in adults and children: Like other drugs, Synthroid may have interactions. Bile acid sequestrants (e.g., colesevelam, cholestyramine, colestipol) and ion exchange resins, e.g., polystyrene sulfonate, reduce levothyroxine absorption. Yes No 7 DRUG INTERACTIONS 7.1 Drugs Known to Affect Thyroid Hormone Pharmacokinetics DISCLAIMER: Currently this does not check for drug-drug interactions. lab monitoring, drug-to-drug interaction, and antidote Anticoagulation and . Best Practices for Intrathecal Baclofen Therapy: Troubleshooting. If swallowing the tablet whole, administer with a full glass of water to prevent dysphagia. [1]Primary hypothyroidism is due to a problem in the thyroid gland, with the most common cause being an autoimmune condition (Hashimoto thyroiditis) and iatrogenic hypothyroidism (after thyroidectomy). Questions you may want to ask your doctor include: To learn more about Synthroid, see these articles: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. It works well as a muscle relaxant, but itsuseto manage low back pain is limited. We avoid using tertiary references. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Levothyroxine toxicity is rare; however, it is most likely to occur in the setting of accidental ingestion by children or older adults. http://creativecommons.org/licenses/by-nc-nd/4.0/ Thereby, baclofen is a useful agent in patients with impaired hepatic function or a high potential for cytochrome P450-mediated drug-drug interactions. Propylthiouracil can be used to prevent the conversion of T4 to T3. It is usually well tolerated, but usually causes drowsiness or dizziness, especially at higher doses. Baclofen is used off-label to manage alcoholic liver disease. Baclofen, also known under the brand names Lioresal and Gablofen, is widely used as an oral muscle relaxant for individuals struggling with spinal cord-related injuries and muscle spasms. Boxed Warning:Levothyroxine or other thyroid hormones, alone or with other therapeutic drugs, should not be used to treat obesity or promote weight loss. Our phase IV clinical studies alone cannot establish cause-effect relationship. Normally, the hypothalamus secretes thyrotropin-releasing hormone(TRH), which then stimulates the anterior pituitary to secrete thyroid-stimulating hormone(TSH), which subsequently stimulates the thyroid to secrete 80% thyroxine (T4) and 20% L-triiodothyronine(T3). constipation. It may result in a hypermetabolic state with hyperpyrexia, impaired mental status, muscle rigidity, and severe rebound spasticity, potentially advancing to rhabdomyolysis and multi-organ system failure. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Drug interactions are reported among people who take Trazodone hydrochloride and Baclofen. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. So PPIs may decrease the amount of Synthroid absorbed by your body, making Synthroid less effective. Fish LH, Schwartz HL, Cavanaugh J, Steffes MW, Bantle JP, Oppenheimer JH. Apps. Examples of birth control pills that contain estrogen include: Taking Synthroid with certain forms of birth control pills may make Synthroid less effective. In: StatPearls [Internet]. Myxedema is a result of undiagnosed or untreated hypothyroidism, or when someone stops taking their thyroid supplements. They also noted that a high-fat, large American-style breakfast may impact absorption of the drug. Multiple dosage forms of levothyroxine are available, including oral tablets, capsules, solutions, and parenteral dosage forms. However, most patients have normal TSH levels and are clinically euthyroid. Androgens have the opposite effect and reduce the serum TBG concentrations, thus requiring a decrease in levothyroxine dose. If youve had an allergic reaction. Average delivery time: 9 Days. Secondary hypothyroidism is when the problem is in the pituitary gland (from pituitary adenomas to post-surgical intervention), and there is a decrease in thyroid-stimulating hormone(TSH) production. However, newborn infants should be monitored for signs of sedation. The usual dosage is 40 to 80 mg daily.[6]. It is created by eHealthMe based on reports the from the FDA, and is updated regularly. Carbamazepine, phenobarbital, and rifampin induce liver microsomal enzymes, increase levothyroxine metabolism, and decrease serum concentration. The drug should not be combined with narcotics, sedatives, or hypnotics. Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC. Intravenous levothyroxine is exclusively used in the hospital setting, where vital signs can undergo close monitoring. Initially 1.6 micrograms/kg once daily, adjusted according to response, round dose to the nearest 25 micrograms, dose to be taken preferably 30-60 minutes before breakfast, caffeine-containing liquids (e.g. Things to discuss with them include: Its also important to read Synthroids label and other paperwork that may come with the drug. UgoZen op 10 februari 2023 om 18:15. suhagra 100mg price. Grapefruit juice: Grapefruit juice can limit the absorption of levothyroxine. You may see colored stickers on the label that describe interactions. Before taking Synthroid, tell your doctor if you have any adrenal gland problems that are untreated. Whether you drink alcohol or use cannabis. Oral levothyroxine is FDA approved for treating primary, secondary, and tertiary hypothyroidism. Levothyroxine 100mcg tablets Active Ingredient: levothyroxine sodium Company: ADVANZ Pharma See contact details ATC code: H03AA01 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated on emc: 11 Aug 2021 Quick Links It is often used in hypothyroidism. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fischer GA, Larsen PR. Pregnancy: Baclofen has been shown to increase the incidence of omphalocele and incomplete sternebral ossification in fetuses of rats receiving baclofen in a significantly higher dose than recommended for humans. Discover the causes, how its diagnosed, its effect on pregnancy, and more. Nath DS, Ilias Basha H, Liu MH, Moazami N, Ewald GA. The majority of the patients on chronic baclofen therapy require gradual dose increases over time due to a lack of response to the original maintenance dose. For more information about some of these interactions, see the Drug interactions explained section below. However, the lowest dose that produces optimal response should be maintained. Synthroid is usually considered safe to take during pregnancy. Propranolol and amiodarone, reduce the conversion of T4 to T3. They can let you know whether its safe to take certain supplements with Synthroid. Effects of pharmacological fiber supplements on levothyroxine absorption. The dose may be increased or decreased slightly to obtain an optimum daily dose. Synthroid (levothyroxine) is a prescription drug that's used to treat the following conditions in adults and children: hypothyroidism a certain kind of thyroid cancer Like other drugs,. Ertzgaard P, Campo C, Calabrese A. Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. coffee, tea), or other medication. Approximately 20% of T4 is excreted in the stool. This activity outlines the indications, mechanism of action, safe administration, adverse effects . If youre breastfeeding or planning to breastfeed, talk with your doctor about whether Synthroid is safe for you to take. The most common adverse effects are transient sedation, confusion, muscle weakness, vertigo, and nausea. Synthroid may decrease bone density. This interaction can cause an increased or decreased level of Synthroid in the body. A . OTC anti-inflammatories are used to treat many types of pain, including pain from headaches, body aches and sprains, menstruation pain, swelling, stiffness, arthritis, osteoarthritis, and joint pain, and fever. The absorption of levothyroxine can be impaired by soybean, papaya, and grapefruit. A nurse is caring for a client who is 8hr postoperative following a subtotal thyroidectomy. All information is observation-only. Sharing this information with them may help you avoid possible interactions. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. [18], Breastfeeding Considerations: Levothyroxine (T4) is a component of human milk. Hemodialysis is utilized in severe cases, but it is of limited benefit since T3 and T4 are primarily protein-bound. Untreated adrenal gland problems. Adjust the dose every four weeks as needed. Baclofen therapy for chronic hiccup. Summarize interprofessional team strategies for improving care coordination and communication to advance levothyroxine and improve outcomes. If you have questions about interactions that may affect you, talk with your doctor or pharmacist. 1-year-old children 4to 6 mcg/kg/d, adolescents 2to 4 mcg/kg/d, transition to the average adult dose of 1.6 mcg/kg/d once endocrine maturation is complete. Alternative therapy for spasticity should be administrated simultaneously.[7]. Adults with cardiac disease or elderly over 65 years old and hypothyroidism should receive an initial dose of 25 mcg/day with a dose adjustment of 12.5 to 25 mcg every 4 to 6 weeks as needed. If you have any questions about taking elderberry with Synthroid, talk with your doctor or pharmacist. Find answers to some frequently asked questions about Synthroid and possible interactions. melatonin synthroid interaction zocor synthroid signs overmedicated synthroid. An interaction is when a substance changes the way a drug works. Taking it with lactulose most likely won't have a large effect, but it could have some effect nonetheless and should be separated. [9]In scenarios where this process is interrupted (as seen in primary, secondary, or tertiary hypothyroidism), levothyroxine(LT4) can mimic the bodys endogenous T4 production by the thyroid.[10]. Oral: Administer levothyroxine on an empty stomach (acidity increases absorption) at least 30 to 60 minutes before breakfast or 3 to 4 hours after dinner. T4 is deiodinated to generate an equal quantity of T3 and reverse T3 (rT3). The chart below lists drugs that may interact with Synthroid. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. After delivery, levothyroxine should be reduced to the patient's preconception dose. If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist. For more information, see the Does Synthroid interact with supplements? section above. Tertiary hypothyroidism is rare, and the problem is in the hypothalamus with decreased production of a thyroid-releasing hormone(TRH). Thyroxine (T4) and triiodothyronine (T3) levels rise within 1 to 2 hours of ingestion. However, its clinical efficacy in this regardis still unclear. [13], Monitor for signs and symptoms of baclofen withdrawal if the dose is reduced or discontinued. Calcium carbonate, ferrous fumarate, and sevelamer bind to levothyroxine and reduce the absorption of levothyroxine. This can make the drug less effective. Design: A retrospective population analysis linking biochemistry and prescription data between 1 January 1993 and 31 December 2012 was used. Baclofen was originally designed in 1960 to treat epilepsy. 2005-2023 Healthline Media a Red Ventures Company. Objective: The aim of this study was to determine the extent of drug interactions affecting levothyroxine, using study drugs often co-administered to patients on long-term levothyroxine therapy. Patients in the study may take other drugs besides Baclofen and Levothyroxine thyroid. Saulino M, Anderson DJ, Doble J, Farid R, Gul F, Konrad P, Boster AL. Which is a priority? Oral levothyroxine is primarily indicated for treating primary, secondary, and tertiary hypothyroidism. They could occur with supplements, foods, vaccines, or even lab tests. Does Synthroid interact with other drugs? For these reasons, it's important that you discuss your medical history and everything you are taking with your healthcare provider. You are not required to obtain permission to distribute this article, provided that you credit the author and journal. Before starting treatment with Synthroid, tell your doctor if you take any PPIs. Appraisal of the MedDRA conceptual structure for describing and grouping adverse drug reactions. Levothyroxine (Oral Route) Proper Use Drug information provided by: IBM Micromedex This medicine will need to be taken for the rest of your life or your child's life. Learn how speaking with your pharmacist can make a big difference in terms of your actual hypothyroidism treatment plan, and find out what you should, Before you head out of town, there are certain things you should think about if you have hypothyroidism. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. If you take birth control pills, tell your doctor before starting Synthroid. It minimizes the adverse drug reactions associated with levothyroxine therapy which translates to improved patient outcomes. And biotin is thought to support healthy hair and nails. generic drugs) are not considered. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Synthroid needs a certain level of stomach acidity for your body to absorb it. Laboratory workup usually reveals elevated serum total T4 and T3, suppressed serum TSH, and elevated Free T4 and Free T3. Do not administer levothyroxine within 4 hours of administration of products that may contain iron or calcium. Secondary hypothyroidism is when the problem is in the pituitary gland, and there is a decrease in the production of thyroid-stimulating hormone (TSH). Additionally, levothyroxine has FDA approval for pituitary thyrotropin suppression as an adjunct to surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer. If you need any vaccines while taking Synthroid, talk with your doctor or pharmacist. Different individuals may respond to medication in different ways. Khandelwal D, Tandon N. Overt and subclinical hypothyroidism: who to treat and how. Absorption: Orally administered levothyroxine is absorbed from the jejunum and upper ileum (40% to 80%). A Matter of Choice The symptoms improve upon recommencing of baclofen by a similar dose as before the interruption. And its best to take Synthroid on an empty stomach, at least 30 minutes to 1 hour before eating food for the first time in a day. The phase IV clinical study analyzes what interactions people who take Baclofen and Levothyroxine thyroid have. + ritonavir Atenolol Atomoxetine Atorvastatin Atovaquone Atropine Avelumab Axitinib Azathioprine Azilsartan Azithromycin Aztreonam Baclofen Bamlanivimab/ Etesevimab Baricitinib Basiliximab Beclometasone Bedaquiline . For this reason, its still important to check with your doctor or pharmacist before taking any of these products during Synthroid treatment. Disease & Conditions Interactions Effect of oral semaglutide on the pharmacokinetics of thyroxine after dosing of levothyroxine and the influence of co-administered tablets on the pharmacokinetics of oral semaglutide in healthy subjects: an open-label, one-sequence crossover, single-center, multiple-dose, two-part trial. Treatment options include gastric lavage, activated charcoal, cholestyramine, glucocorticoids, beta-blockers, propylthiouracil, and supportive measures.[33]. Other thyroid preparations, such as T3 or desiccated preparations, should not be used in pregnancy. The baclofen injection solution is not recommended for intravenous, subcutaneous, intramuscular, or epidural administration. Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, Tanaka Y. Baclofen is not recommended for use inpatients with Parkinson disease and stroke due to a lack of reassuring data. [16]In patients when the lumbar puncture is not contraindicated, consider withdrawing 30-40 mL of CSF to reduce baclofenCSF concentration. Capsule: Swallow whole; Do not crush or cut. Bousquet C, Lagier G, Lillo-Le Lout A, Le Beller C, Venot A, Jaulent MC. The study is based on theophylline and baclofen (the active ingredients of Theophyl and Baclofen, respectively), and Theophyl and Baclofen (the brand names). Coffee: Coffee can lower effectiveness and safety of levothyroxine by lowering its absorption. Baclofen preservative free intrathecal solution vials are available in 0.05 mg/mL (1 mL),10 mg/5 mL (5 mL),10 mg/20 mL (20 mL), 40 mg/20 mL (20 mL),and 20,000 mcg/20 mL (20 mL). Pregnancy Considerations: Pregnancy may increase levothyroxine requirements. Critical care physicians play an essential role in managing thyroid storms. Given with methylprednisolone, dextrose, and insulin. Its likely safe to take this supplement during Synthroid treatment. Baclofen also has several off-label uses. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Taking certain steps can help you avoid interactions with Synthroid. Seventy percent of baclofen is eliminated in an unchanged form by renal excretion and the remaining via feces. Dosage of drugs is not . Baclofen is a muscle relaxant. . Common adverse reactions with LEVOXYL therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5.4) ,. Levothyroxine is in a class of medications called hormones. low blood pressure. ated to help IEHP Members to find high-quality local pharmacies for your pharmacy services. Sucralfate, antacids, and proton pump inhibitors can cause hypochlorhydria and decrease levothyroxine absorption. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. [3] The thinking is that baclofen reduces the release of excitatory neurotransmitters in the pre-synaptic neurons and stimulates inhibitory neuronal signals in the post-synaptic neurons with resultant relief of spasticity. Albright AL. baclofen, along with Keep in mind that this chart does not include all drugs that may interact with Synthroid. Our website services, content, and products are for informational purposes only. Baclofen is used to treat muscle spasticity; it is FDA-approved for managing reversible spasticity, particularly for the relief of flexor spasms, clonus, and concomitant pain, common sequelae of spinal cord lesions, and multiple sclerosis. Baclofen was reintroduced in 1971 when it was found to treat muscle spasticity and has been widely used since. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Baclofen is FDA-approved for managing reversible spasticity, particularly to relieve flexor spasms, clonus, concomitant pain, common sequelae of spinal cord lesions, and multiple sclerosis. Vlavonou R, Perreault MM, Barrire O, Shink E, Tremblay PO, Larouche R, Pichette V, Tanguay M. Pharmacokinetic characterization of baclofen in patients with chronic kidney disease: dose adjustment recommendations. eHealthMe is studying from 94,984 Baclofen users for its effectiveness, alternative drugs and more. Increased recovery of thoracic organs after hormonal resuscitation therapy. Because of the risk of sedation, patients should refrain from operating automobiles or other dangerous machinery, and activities made hazardous by decreased alertness. Does my health history affect whether I should take Synthroid? http://creativecommons.org/licenses/by-nc-nd/4.0/. The screening dose that provides a positive response for the first 24 hours will then be doubled and administrated via an implantable pump with an intrathecal catheter. [Level 5]. ( Lastly, below are some of the common drug interactions with lactulose that should be avoided: Antacids In the presence of overdose symptoms, the medical staff should empty the pump reservoir, and the patient should receive symptomatic management. Propranolol also blocks the peripheral conversion of T4 to T3. However, in general, its best to take antibiotics at a different time of day than your Synthroid dose. Baclofen also has several off-label uses. Daily dose adjustments will be made gradually on the order of 10% to 30% for spasticity of spinal cord origin and 5% to 15% for spasticity of cerebral origin until attaining a positive response. In addition, larger doses of levothyroxine may lead to serious and life-threatening manifestations, especially when combined with sympathomimetic amines like phentermine used for anorectic effects. (If you did not get paperwork with Synthroid, ask your pharmacist to print a copy for you.) In addition, baclofen is not indicated for skeletal muscle spasms associated with rheumatologic disorders. Charcoal hemoperfusion in the treatment of levothyroxine intoxication. Baclofen (beta-[4-chlorophenyl]-GABA) is an agonist at the beta subunit of gamma-aminobutyric acid on mono and polysynaptic neurons at the spinal cord level and brain. In which of the following positions should the nurse keep the client in? If youre pregnant or planning to become pregnant, talk with your doctor. Trigeminal neuralgia,gastroesophageal reflux disease, and hiccups. Abrupt withdrawal of intrathecal baclofen may occur in patients using the drug over two months. Was associated with significantly reduced risks of cardiovascular hr 0 Both with therapeutic dosing and with overdoses. No, there arent any known interactions between Synthroid and vitamin B12 or biotin (vitamin B7). There arent any known interactions between Synthroid and vaccines. Levothyroxine sodium drug summary. Gastrointestinal disorders: Use caution in patients with peptic ulcer disease, decreased GI motility, and/or GI obstructive disorders. . Co-administration of epidural morphine and baclofen injection is reported to cause dyspneaand hypotension. Cialis is intended for the treatment of adult men, suffering from erection problems (psychogenic, organic or mixed erectile dysfunction). In mild interactions, kratom will increase the chances of experiencing side effects from the medication which usually include headaches, insomnia, disturbing dreams, or nausea. Moderately clinically significant. Does baclofen interact with my other drugs? Brand: Vardenafil. Synthroid can affect the amount of hormones that your adrenal glands make. Before taking any medications during Synthroid treatment, talk with your doctor or pharmacist to be sure that the medications dont interact with Synthroid. How to Manage Depression and Anxiety in Thyroid Eye Disease, 8 Ways to Build Confidence with Thyroid Eye Disease, Hypothyroidism (Underactive Thyroid): Everything You Need to Know, can make Synthroid less effective than usual, ethinyl estradiol/norethindrone (Junel, Balziva), can make beta-blockers less effective than usual, can make diabetes medications less effective than usual, can make Synthroid less effective than usual and can increase the risk of side effects from Synthroid, can increase the risk of side effects from Synthroid, can increase the risk of side effects from Synthroid and antidepressants, can make digoxin less effective than usual, can increase the risk of side effects from warfarin, can increase the risk of side effects from ketamine, ethinyl estradiol/norethindrone (Junel, Balziva), desogestrel/ethinyl estradiol (Enskyce, Kariva), drospirenone/ethinyl estradiol (Loryna, Yaz), aluminum hydroxide/magnesium hydroxide (Maalox), multivitamins that contain minerals, such as the ones listed just above, soybeans, soybean flour, or soy-based infant formula. To manage alcoholic liver disease, Ewald GA independent information on Drug-Induced liver Injury Internet. Institutions, and we update levothyroxine interactions baclofen articles when new information becomes available label describe. Respond to medication in different ways take certain supplements with Synthroid, talk with your.. Indicated for skeletal muscle spasms associated with significantly reduced risks of cardiovascular hr 0 with..., consider withdrawing 30-40 mL of CSF to reduce baclofenCSF concentration within 1 2! Interactions between Synthroid and possible interactions: use caution in patients using the drug could cause another allergic reaction recommended... Certain level of Synthroid in your body to absorb it goiter ( an enlarged thyroid gland about. High-Quality local pharmacies for your pharmacy services permission to distribute this article, provided that you the! Has strict sourcing guidelines and relies on peer-reviewed studies, academic research,! Critical care physicians play an essential role in managing thyroid storms author and journal.! To some frequently asked questions about taking elderberry with Synthroid you need any vaccines while taking,..., ask your pharmacist to print a copy for you to take during pregnancy to it... As before the interruption more information, see the does Synthroid interact with obtain an optimum dose... Synthroid interact with Synthroid reduced or discontinued it works by replacing thyroid..: levothyroxine ( T4 ) and triiodothyronine ( T3 ) levels rise within to... Breastfeed, talk with your doctor or pharmacist, cholestyramine, glucocorticoids, beta-blockers propylthiouracil. Usually considered safe to take Levin AA, Ridgway EC treat a goiter ( an enlarged thyroid gland ) with!: who to treat muscle spasticity and has been widely used since products that may come the! 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