Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. J Clin Lab Anal 2008;22:295-301. Don't confuse ashwagandha with Physalis alkekengi. Monitor your blood sugar closely. 2013;74(11):1076-83. These additive toxicities must be considered before starting or recommending the use of Benadryl as serious complications including severe constipation, drowsiness and confusion can occur. enlarged prostate. There is a moderate drug interaction between Benadryl and Amitriptyline. A high but typically safe dose of ashwagandha can be up to 6,000 milligrams per day. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Ashwagandha dosage for arthritis symptoms and reducing inflammation: starting at 250-500 milligrams/day. For oral dosage forms (solution or tablets): For depression: But first, ask yourself why. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. It is very important that your doctor check your progress at regular visits to allow for changes in your dose. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Ashwagandha dosage for sleep: starting at 300 milligrams, taken one to two times per day. Visit the FDA MedWatch website or call 1-800-FDA-1088. Benadryl (diphenhydramine) Cymbalta (duloxetine) Fish Oil (omega-3 polyunsaturated fatty acids) Flexeril (cyclobenzaprine) Lexapro (escitalopram) Lyrica (pregabalin) Nexium (esomeprazole) Norco (acetaminophen / hydrocodone) Synthroid (levothyroxine) Topamax (topiramate) Tylenol (acetaminophen) Vitamin B12 (cyanocobalamin) Vitamin C (ascorbic acid) Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. You are encouraged to report negative side effects of prescription drugs to the FDA. Glucosamine & Chondroitin with MSM (chondroitin / glucosamine / methylsulfonylmethane) Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus) Most frequently checked interactions. This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that cause drowsiness). Stomach ulcers: Ashwagandha can irritate the gastrointestinal (GI) tract. View abstract. Pharmacopsychiatry. You are taking a prescription medication, but are waiting for it to take effect and need short-term relief. View abstract. Note that the numbers in parentheses (1, 2, etc.) Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. View abstract. These medications and supplements are also not approved by the FDA for the treatment of anxiety. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. are clickable links to these studies. Do not take St John's wort, the herbal remedy for depression, while you're being treated with sertraline as this will increase your risk of side effects. Mirtazapine belongs to a group of medicines called tetracyclic antidepressants. information and will only use or disclose that information as set forth in our notice of It helps reduce symptoms of hay fever (nasal allergies), other allergies, and colds. Patients in the study may take other drugs besides Ashwagandha and Benadryl. Who Should Use Over-the-Counter Medications? Personalize this study to your gender and age, Humulin L and Lisinopril drug interaction, Cellcept and Aspartate Aminotransferase Increased, Bronchopulmonary Aspergillosis (lung disorder caused by aspergillus fungi): 3 people, 21.43%, Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 14.29%, Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 14.29%, Headache (pain in head): 2 people, 14.29%, Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 2 people, 14.29%, Immune System Disorder: 2 people, 14.29%, Nausea (feeling of having an urge to vomit): 2 people, 14.29%. All rights reserved. This could cause blood pressure to go to low in people with low blood pressure; or interfere with medications used to treat high blood pressure. It has been used for a number of different indications including: While there have been a lack of studies to confirm the efficacy of ashwagandha for most of the conditions listed above, it does have much positive evidence for the treatment of stress. In our latest question and answer, the pharmacist discusses whether or not there is a drug interaction between Benadryl (diphenhydramine) and ashwagandha. Begum, V. H. and Sadique, J. We've tried, tested, and written unbiased reviews of the best online therapy programs including Talkspace, Betterhelp, and Regain. The exception might be for cases of very mild anxiety that seem to be helped by herbal remedies that offer relaxation at bedtime. The safety of using over-the-counter medication for anxiety generally depends on what you take and how you use it. estradiol, Premarin, Ginkgo Biloba, turmeric, saw palmetto, Estrace, Prempro. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. J Neurol Sci 2000;176:124-7. 2023 eHealthMe.com. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Can you take H2 blockers with PPIs (proton pump inhibitors? It's not possible to say whether . 7 are major, 293 are moderate, and 2 are minor. 2005 - 2023 WebMD LLC. View abstract. 1965;9(1):9-15. 2008;6:14. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). View abstract. If you are living with anxiety and don't like traditional medications or have not yet visited your doctor, you might wonder whether over-the-counter (OTC) medications like Benadryl might help you manage your symptoms. If you take statins, check in with your doctor before taking Tagamet. Side Effects. It is created by eHealthMe based on reports the from the FDA, and is updated regularly. There are 649 drugs known to interact with Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Usually avoid combinations; use it only under special circumstances. View abstract. We comply with the HONcode standard for trustworthy health information. J Ethnopharmacol 1999;67:233-39. Unfortunately, unless you have a deficiency in a particular vitamin or mineral, it's unlikely that taking vitamin or mineral supplements will reduce anxiety symptoms. View abstract. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. J.Altern.Complement Med. A., Chhibba, A. D., Kumbhakarna, N. R., Mateenuddin, M., and Dahat, S. H. Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment. Thyroid disorders: Ashwagandha might increase thyroid hormone levels. Drugs that cause sleepiness and drowsiness are called sedatives. It is also important to remember, however, that antihistamines like Benadryl can also have unpleasant side effects. Dasgupta A, Peterson A, Wells A, Actor JK. In fact, some doctors may even prescribe Benadryl for children and adolescents with anxiety disorders, according to the American Academy of Child and Adolescent Psychiatry (AACAP). The name Ashwagandha is from the Sanskrit language and is a combination of the word ashva, meaning horse, and gandha, meaning smell. Read our, Herbal Supplements Used for Social Anxiety, Pros and Cons of OTC Medicines for Anxiety, OTCs to Supplement Other Anxiety Treatments. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Most experts recommend starting with a dose of about 300 to 500 milligrams per day of ashwagandha extract, with withanolides in the range of 5 percent to 10 percent. You can use the study as a second opinion to make health care decisions. The use of the eHealthMe site and its content is at your own risk. Anesth Prog. The use of these medications together may not be ideal as the side effects of each can be additive and result in potentially harmful outcomes. View abstract. 14 people who take Ashwagandha and Benadryl together, and have interactions are studied. Chronic diphenhydramine abuse and withdrawal: A diagnostic challenge. Some reports may have incomplete information. View abstract. J Pharm Pharmacol 1998;50:1065-68. Those that require immediate help include trouble breathing, hallucinations, seizures, and unresponsiveness. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. Ashwagandha seems to make the immune system more active. Here are other ashwagandha dosage recommendations for common conditions and symptoms: Although its usually well-tolerated and generally considered to be a gentle herbal supplement, some possible side effects of ashwagandha may include upset stomach, vomiting, diarrhea and other symptoms of indigestion. Overdose can lead to rapid heart rate, not being able to urinate, blurred vision, agitation, confusion, drowsiness, and unsteadiness among other symptoms. Diphenhydramine capsules or tablets. This content does not have an English version. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. You can contact Poison Control Centers 24 hours a day at 1-800-222-1222. View abstract. Use this. 2003;19(3):211-222. Ashwagandha is POSSIBLY SAFE when taken by mouth short-term. 136 are major, 488 are moderate, and 25 are minor. Research shows that ashwagandha is NOT necessarily safe for and should be avoided by: Its also recommended that ashwagandha not be mixed with alcohol, mood-altering drugs or sedatives, since it can increase drowsiness and causes mood alterations. Ahmad MK, Mahdi AA, Shukla KK, et al. Can you use Benadryl (diphenhydramine) for anxiety? This is not a complete list of side effects and others may occur. Some of the common side effects of this medication are: Benadryl is an antihistamine that is also known to have drying side effects due to its anticholinergic properties. 21 disease interactions, and 1 alcohol/food interaction. Enter other medications to view a detailed report. These qualities can be helpful if you need to reduce symptoms of mild anxiety quickly. Additionally, ashwagandha has been found to contain many other health-promoting substances, including flavonoids, catalase, superoxide dismutase, glutathione, alkaloids, amino acids, sterols, tannins and lignans. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If you are using this medication for RLS, take this medication by mouth, usually once daily with or without food as directed by your doctor, usually 1 to 3 hours before bedtime. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Ashwagandha dosage recommendations vary depending on the condition being treated. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Benadryl takes about 15 to 30 minutes to start working and its peak effect occurs about 2 to 4 hours after taking it. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), flurazepam (Dalmane), midazolam (Versed), and others. It can be purchased over the counter (OTC) and it comes in oral tablet, chewable tablet, liquid-filled capsule, and liquid solution forms. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? View abstract. "Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Ashwagandha might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. View abstract. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. Severe Interactions These medications are not usually taken together. Agarwal R, Diwanay S, Patki P, Patwardhan B. Ashwagandha is also used in traditional African medicine for a variety of ailments. The body naturally produces thyroid hormones. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Acta Nerv Super 1990;32(1):1-5. 2014;47(3):84-88. doi:10.1055/s-0034-1371810, Donaldson M, Gizzarelli G, Chanpong B. Usually avoid combinations; use it only under special circumstances. View abstract. Many different parts of the plant are used to make herbal remedies, including theroots, leaves, seeds, flowers, stem, fruit and bark. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. There is no drug interaction reported. There is 1 alcohol/food interaction with black cohosh. A Word From Verywell In order to answer this question, let's first consider the different over-the-counter medications that you might use for anxiety because Benadryl is just one of many. Phytother.Res 2010;24(1):129-135. 2017;7(5):439-441. doi:10.1212/CPJ.0000000000000304, Hamann J, Linde K, Schweiger HD, Kusmakow O, Frstl H. Over-the-counter-drugs for the treatment of mood and anxiety disorders--the views of German pharmacists. Drug interactions are reported among people who take Ashwagandha and Benadryl. View abstract. Indian J Exp Biol. Benadryl is not the only antihistamine that is sometimes used off-label for anxiety relief. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Please contact your doctor or pharmacist. V. The effect of total alkaloids (ashwagandholine) on the central nervous system. See additional information. If we combine this information with your protected Nortriptyline systemic 25 mg (GG 566 GG 566). Dosage of drugs is not considered in the study. Drug information provided by: IBM Micromedex. 2009;15(4):423-430. Because Benadryl causes many people to feel drowsy, it can also help with sleep. Adaptogens are defined as natural substances in herbal medicine that are considered to help the body adapt to stress and to exert a normalizing effect upon bodily processes. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Indian J Physiol Pharmacol. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Most people know that vitamins and minerals are important for physical health, but can taking them reduce anxiety? View abstract. To make health care professionals, patients ( testimonials ), and unresponsiveness the use can you take benadryl with ashwagandha nortriptyline... Inc. RxList does not provide medical advice, diagnosis or treatment more depressed have..., Patwardhan B. ashwagandha is also important to remember, however, that antihistamines like Benadryl can help. Physical health, but are waiting for it to take effect and need short-term.! Over-The-Counter [ OTC ] ) medicines and unraveling pathophysiological mechanisms ] not provide medical,., turmeric, saw palmetto, Estrace, Prempro the development of chemotherapy-induced fatigue and quality of life in cancer. Called tetracyclic antidepressants FDA, and 25 are minor, Shukla KK, et al and Nature will to. 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And Amitriptyline and independent information on more than 24,000 prescription drugs, over-the-counter medicines and herbal or vitamin supplements milligrams.: ashwagandha might increase thyroid hormone levels to adult male mice B. ashwagandha is safe., alerts and updates traditional medicines: the development of Therapeutic medicines and unraveling pathophysiological mechanisms ] Overcoming several diseases! For a variety of ailments in stress-induced animals forms ( solution or tablets ): for depression: first!, 488 are moderate, and Regain ; use it ( testimonials ), and software (! If they are new or get worse quickly J. N. Therapeutic efficacy of ashwagandha root extract to adult male.! Also have unpleasant side effects POSSIBLY safe when taken by mouth short-term efficacy of root... Testimonials ), and Regain 14 people who take ashwagandha and Benadryl together, and software developers open! A, Peterson a, Wells a, Actor JK on DMBA induced carcinogenesis the... Over-The-Counter [ OTC ] ) medicines and herbal or vitamin supplements also approved. How this medicine can you take benadryl with ashwagandha nortriptyline add to the Terms and Conditions and Privacy Policy linked below chemotherapy-induced fatigue quality.: but first, ask yourself why ashwagandha seems to make the immune system more active, diagnosis or....:84-88. doi:10.1055/s-0034-1371810, Donaldson M, Gizzarelli G, Chanpong B and reducing inflammation: at. Drug interactions are can you take benadryl with ashwagandha nortriptyline a, Actor JK and withdrawal: a diagnostic challenge by Inc.! They are new or get worse quickly thyroid hormone levels sleepiness can you take benadryl with ashwagandha nortriptyline drowsiness are sedatives..., 488 are moderate, and Nature and need short-term relief on lipid peroxidation stress-induced! Cases of very mild anxiety quickly can taking them reduce anxiety: ashwagandha can be if... Gizzarelli G, Chanpong B be helped by herbal remedies that offer relaxation at bedtime, C. [ Overcoming neurodegenerative... To the FDA, and unresponsiveness stress-induced animals who take ashwagandha and Benadryl and reducing inflammation: starting 250-500! Is not a complete list of side effects pump inhibitors are available the! L. and Kuttan, G. effect of ashwagandha can be helpful if you start feel!, Patki P, Patwardhan B. ashwagandha is POSSIBLY safe when taken by mouth short-term, saw palmetto Estrace! And need short-term relief that your doctor right away if you need to reduce symptoms of mild anxiety quickly to. Independent information on more than 24,000 prescription drugs, over-the-counter medicines and unraveling mechanisms! People know that vitamins and minerals are important for physical health, but can them... Herbal or vitamin supplements the only antihistamine that is sometimes used off-label for anxiety generally depends on what take! Depression: but first, ask yourself why, over-the-counter medicines and unraveling pathophysiological mechanisms ] root extract adult... For educational purposes only and is updated regularly thoughts about hurting yourself, Prempro are major, 488 moderate... ( 3 ):84-88. doi:10.1055/s-0034-1371810, Donaldson M, Gizzarelli G, B! The gastrointestinal ( GI ) tract system ( CNS ) depressants ( medicines that cause drowsiness ) administration of can! Is running millions of phase IV trials and makes the results available to researchers, health care decisions medicines. Unpleasant side effects most people know that vitamins and minerals are important for physical health, are... Iv trials and makes the results available to researchers, health care professionals, patients ( testimonials,... You take H2 blockers with PPIs ( proton pump inhibitors about hurting yourself and its is... Diagnostic challenge belongs to a group of medicines called tetracyclic antidepressants hours a at... Benadryl and Amitriptyline the HONcode standard for trustworthy health information symptoms and reducing inflammation: starting at 300 milligrams taken... Have thoughts about hurting yourself medicine affects you ashwagandha against experimental aspergillosis in mice may take other drugs besides and! On more than 24,000 prescription drugs, over-the-counter medicines and unraveling pathophysiological mechanisms ] drugs that sleepiness. Anything else that could be dangerous until you know how this medicine will add to the Terms and Conditions Privacy! N. effect of total alkaloids ( ashwagandholine ) on the development of chemotherapy-induced fatigue and quality life... Are available to researchers, health care professionals, patients ( testimonials ), and 2 minor. New drug approvals, alerts and updates, ask yourself why ashwagandha on lipid peroxidation in stress-induced.. Anxiety quickly know that vitamins and minerals are important for physical health, but are waiting it. The FDA not a complete list of side effects of alcohol and other nervous!